CHEMICAL OXIDATION OF PHENYLEPHRINE BY USING CHLORAMINE-T IN ACID MEDIA: A KINETIC AND MECHANISTIC STUDYAbstract
The kinetics and mechanism of oxidation of Phenylephrine (PHE) by Chloramine-T (CAT) in acid media have been investigated by spectroscopic technique at the temperature of 298 K. It is found that the reaction is of first order with respect to PHE, fractional order with respect to CAT & inverse order with respect to H+. The reaction rate remained unchanged with the variation of ionic strength of the medium indicating that the non ionic species are involved in the rate determining step. The rate of reaction decreases with increase in concentration of dielectric constant. Addition of chloride ions had no effect on rate of reaction. The stoichiometric ratio was found to be 1:1(PHE: CAT) ratio. The major oxidation product of PHE has been identified by an UV, Cyclic voltammetry (CV), IR, H1 NMR and Mass spectroscopy. On the basis of the experimental results, a suitable mechanism has been proposed. The rate constants of the rate-determining step together with the activation parameters were evaluated and also thermodynamic quantities were determined.
M. S. Veena, M. K. Prashanth, B. K. Jayanna, K. Yogesh Kumar, Y. Arthoba Nayaka and H. B. Muralidhara
Centre for Incubation, Innovation, Research and Consultancy (CIIRC), Jyothy Institute of Technology, Thataguni, Kanakapura Road, Bengaluru, Karnataka, India
07 September, 2016
02 November, 2016
06 December, 2016
01 March, 2017