CHRONIC KIDNEY DISEASE AND COGNITIVE STATUSAbstract
Background: The relation between Chronic Kidney Disease (CKD) and cognitive impairment is an important public health issue because the prevalence of CKD is increased worldwide. In recent years, chronic kidney disease has been proposed as an independent risk factor for cognitive decline but the available data are conflicting. In the present study, we examined the relations of CKD and lower renal filtration function with a broad range of cognitive functions in a dementia-free community-based population. Methods: A cross-sectional, observational, questionnaire based study was conducted at Nephrology department of Govt. Medical College, Calicut. Montreal Cognitive Assessment Questionnaire was used to assess cognitive status. Patient’s divided into 5 groups depending on stage of chronic kidney disease. Estimated glomerular filtration rate was calculated using modification of diet in renal disease equation. Results: 210 patients were enrolled in the study. 53.8% have mild cognitive impairment and 46.2% have normal cognitive status. Education with cognitive status was found to be statistically significant (P=0.000). Conclusion: Decreased kidney function associated with greater cognitive decline, even in those with mild CKD. Further studies are needed to determine the reasons for cognitive impairment in subjects with CKD.
P. C. Viji *, K. Sreejith and M. Sreelatha
Department of Pharmacy Practice, College of Pharmaceutical Sciences, Government Medical College, Calicut, Kerala, India.
11 October, 2016
07 December, 2016
16 December, 2016
01 May, 2017