CHRONOTHERAPEUTIC SYSTEMS: NOVEL SYSTEMS OF DRUG DELIVERYAbstract
Chronotherapeutic systems are meant for the treatment of most of the diseases that occurred and found till date, which are proved to be in association with the biological/circadian rhythms of our body with respect to disease symptoms and their severity. Such diseases use this treatment as it involves in-vivo drug availability with distinctive release patterns so as to match the rhythms of disease and achieve optimized therapeutic outcomes with minimized side effects. The specific time at which patients take their medications is taken into consideration as it is the main reason for the treatment success. There is a synchronization of pharmacodynamics and pharmacologic activity of drugs with that of the biological clock, so variations in disease state and plasma drug concentration are taken into consideration during the development of this drug delivery system. Various novel technologies are employed in developing Chronotherapeutic devices and dosage forms, some are available in the market already, and many others are yet to arrive. The main objective of this review is to explore the current status of Chronotherapeutic technologies and also to provide a view on various variations in dosage forms that contribute for chronotherapy.
Santosh Kumar Rada * and Shambhavi Kandukuri
Department of Pharmaceutics, GITAM Institute of Pharmacy, GITAM (Deemed to be University), Rushikonda, Vishakhapatnam , Andhra Pradesh, India.
30 January 2021
10 May 2021
29 May 2021
01 January 2022