CINNAMALDEHYDE, THE MAJOR COMPONENT OF CINNAMOMUM ZEYLANICUM, AFFECTS INFLAMMATORY PATHWAYSAbstract
Cinnamaldehyde is the aldehyde that gives cinnamon its flavour and odour. It occurs naturally in the bark of cinnamon tree (Cinnamomum zeylanicum), a common Indian spice. The essential oil of cinnamon bark contains about 90% of cinnamaldehyde. It exists as a yellow oily liquid with a cinnamon odor and sweet taste and is traditionally known to have many medicinal properties, although the mechanism of action is not completely understood. Macrophages are one of the most important cells of the immune system and play important role in influencing the inflammation cascade process. The current study aimed towards understanding the role of this medicinal plant product on genes of the inflammatory pathways, especially in the context of macrophages. For this purpose, the effects of Cinnamaldehyde were studied on the macrophage cell line J774A.1. Our studies indicate that treatment of these cells with various concentrations of Cinnamaldehyde alters levels of the pro-inflammatory cytokine, IL-12. Further studies are required to get a better understanding of the molecular mechanisms by which Cinnamaldehyde may be able to impart its medicinal effects on the process of inflammatory response.
S. Mahapatra, S. Roy, P. Chakraborty, N. Chakraborty, U. Paul, P. Chatterjee, S. Banerjee, P. Sarkar and M. Bhattacharya *
Department of Bio-Technology, Techno India University, Kolkata, West Bengal, India.
10 November 2019
29 March 2020
31 March 2020
01 November 2020