CLINICAL EVIDENCES OF OXIDATIVE STRESS AS A BIOMARKER IN VARIOUS TYPES OF CANCERS: A REVIEWAbstract
Free radicals play an effective role in the pathogenesis of different pathological diseases together with cancer. Potential biological targets for free radical attack comprise lipids, proteins and nucleic acids. Free radical induced lipid peroxidation causes a loss of cell homeostasis by modifying the structure and functions of cell membrane. The most important characteristic of lipid peroxidation is to cause a substantial DNA- MDA (Malondialdehyde) adducts by interacting with cellular DNA. Enzymatic antioxidants Superoxide dismutase (SOD), Catalase (CAT), Glutathione peroxidase (GPx) and non-enzymatic antioxidants vitamin E, Reduced glutathione (GSH) proceed synergistically with one another to detoxify the effects of lipid peroxidation. There is occurrence and contribution of oxidative stress in different types of cancer including, Ovarian cancer, Breast cancer, Oral cancer, Lung cancer, Leukemia, Cervical cancer, Prostate cancer, Gastric and Colon cancer which increase the pathogenesis and cause tissue damage in cancer. Lipid peroxidation and levels of enzymatic and non-enzymatic antioxidants can be used as markers of oxidative stress in various cancers.
Sachin Sharma , Archana Shrivastav and B.R. Shrivastav*
Director, Cancer Hospital & Research Institute, Gwalior, Madhya Pradesh, India
01 October, 2013
21 November, 2013
16 February, 2014
01 March, 2014