COENZYME Q10: A POTENTIAL BREAKTHROUGH IN PHYSIOLOGICAL DYSFUNCTIONSAbstract
Coenzyme Q10 (ubiquinone) is a lipophilic benzoquinone substance. It is a pivotal component to the oxidative phosphorylation in the inner mitochondrial membrane of all aerobic cells as well as diminishes reactive oxygen species (ROS). Exogenous sources for CoQ10 are grapes seed oil, walnuts, pistachios, spinach, and sesame seed. At present, it is being utilized as an antioxidant agent. Recent studies have revealed its neuroprotective action. In the present review, the comprehensive pharmacological benefits of coenzyme Q10 on the central nervous system (CNS) has been revealed. Many studies were taken into considerations and compiled in accordance with their activities. Amongst those, the study using in-vitro models referring to neuronal toxicity and animal models of neurodegenerative diseases have been covered. Multiple outcomes have now evolved assisting the role of reactive oxygen species and neuroinflammation in the pathogenesis of the neurodegenerative disorder. The drug coenzyme Q10 has been administered in a human subject with reference to their age and body weight. In case of increased oxidative stress and few selective cases of gene mutation, the energy production in mitochondria is highly impaired and the deficiency also happens in brain cells which is a leading cause in pathogenesis of premature aging and neurodegenerative diseases. Potential neuroprotective effects of coenzyme Q10 have also been emphasized in several neurodegenerative disorders such as Parkinson’s disease (PD), Huntington’s disease and Alzheimer’s disease (AD). This article contributes a pervasive review on the utility of coenzyme Q10 in the management as well as in the prevention of many illnesses as for example, hyperlipidemia, coronary artery disease, myocardial infarction and kidney disease.