COLON DRUG DELIVERY SYSTEM, ADVANCE DEVELOPMENT AND EVALUATION: A REVIEWAbstract
Colon targeted drug delivery system is a significant part of the pharmaceutical dosage form. Because the colon targeted formulation system only responds to the colon-specific physiological conditions, a triggering mechanism is required. Site of colon provides local and systemic drug delivery. Inflammatory bowel disease can be treated by localized delivery of drugs. The systemic side effect can be decreased by aiming the medications directly to the colonic cycle. Rectal and oral formulations are the major drug targeting strategies that target the colon by pressure, pH, and micro-flora triggered the release of the drug. Formulation of colon targeted system is a complicated process involving substantial efforts. This article discusses the advantages, limitations, primary and advanced approaches, and evaluation of colon-specific systems and provides information regarding some of the formulations available in the market to treat colon-related disorders. This article also focuses on current and future prospects in the area of colon-targeted formulations.
A. Jain *, A. Mittal and D. Ghosh
Meerut Institute of Engineering and Technology, Meerut, Uttar Pradesh, India.
18 April 2020
24 September 2020
28 September 2020
01 April 2021