COLON SPECIFIC DRUG DELIVERY SYSTEM: AN APPROACH TO TARGET COLONIC DISEASESAbstract
Drug as such, may not show the desired therapeutic effect; drug delivery is the method or process of administering a pharmaceutical compound to achieve a therapeutic effect in humans or animals. Targeted drug delivery into the colon is highly desirable for local treatment of a variety of bowel diseases such as ulcerative colitis, Crohn’s disease, amoebiasis, colonic cancer, local treatment of colonic pathologies, and systemic delivery of protein and peptide drugs. Colon targeted drug delivery system (CTDDS) can deliver drugs as both local and systemic. Local delivery, in the treatment of inflammatory bowel disease (IBD). Treatment could be enhanced when drug delivered to the target site on the colon. Systemic side effects could also be reduced. Colon-specific systems are the most important delivery of those drugs which are normally inactivated in the upper parts of the gastrointestinal tract (GIT). Primary approaches for CTDDS (Colon Targeted Drug Delivery System), which includes prodrugs, pH and time-dependent systems, bacterial enzyme dependent colonic DDS and pH and bacterial enzyme dependent colonic DDS. The novel approach of CTDDS, which includes pressure controlled colonic delivery capsules (PCDCS), osmotic controlled drug delivery are specific techniques.
N. R. Kar * and S. C. Dinda
School of Pharmaceutical Education and Research (SPER), Berhampur University, Bhanja Bihar, Berhampur, Ganjam, Odisha, India.
11 January 2019
19 February 2019
24 February 2019
01 March 2019