COLON SPECIFIC DRUG DELIVERY SYSTEM: REVIEW ON NOVEL APPROACHESAbstract
Article reviews the research focus on potential opportunities and challenges available in new area of colon targeted drug delivery system. Colon was considered as “BLACK BOX” as, most of drugs are absorbed from upper part of GIT tract. Targeted drug delivery to the colon would ensure direct treatment at the disease site, lowering of dose and lesser systemic side effects. In addition, the colon can also be utilized as a portal for the entry of drugs into the systemic circulation. This review, mainly compares the primary approaches for CDDS (Colon Specific Drug Delivery) namely pro drugs, pH and time dependent systems, and microbially triggered systems, which achieved limited success and had limitations as compared with newer CDDS namely pressure controlled colonic delivery capsules, CODESTM, and osmotic controlled drug delivery which are unique in terms of achieving in vivo site specificity,and feasibility of manufacturing process.
Karan Inder Singh*, Jagpreet Singh, Daisy Sharma, Anil Sharma
155, Raj Nagar, Basti Bawa Khel, Jalandhar, Punjab, India
21 October, 2011
30 December, 2011
17 February, 2012