COLON TARGETED DRUG DELIVERY: CURRENT AND NOVEL PERSPECTIVESAbstract
In general, we know that small intestine is mostly the site for drug absorption but in some cases the drug needs to be targeted to some other sites for absorption due to various factors like any disease condition, degradation related situations, for sustained release of drugs etc. Colon targeted drug delivery is a relatively new concept for the absorption of drugs as it offers near neutral pH. Also it offers long residence time, thereby increasing the drug absorption. The nature of food and enzymes does not affect the drug absorption. Colon has proved to be a site for the absorption of poorly soluble drugs. For the successful targeting of drugs to colon the dosage form should be designed such that it prevents the drug release in upper GIT and releasing it in the colonic region. This review article comprises of the various aspects of colon targeting which we should know before experimenting the technique and their IVIVC using recent evaluation models through x-ray imaging and gamma-scintigrapy.
Surender Verma , Vipin Kumar*, D. N. Mishra and S. K. Singh
Associate Professor, Institute of Pharmaceutical Sciences, Kurukshetra University, Kurukshetra, Haryana, India
21 January, 2012
29 March, 2012
19 April, 2012
01 May, 2012