COLON TARGETED DRUG DELIVERY SYSTEM: A REVEIW ON PRIMARY AND NOVEL APPROACHESAbstract
In the recent years there is new development in field of colon specific drug delivery system. The colon is the terminal part of the GIT which has gained as a potential site for delivery of various novel therapeutic drugs. The colon is a site where both local and systemic delivery of drugs can take place. Local delivery allows topical treatment of inflammatory bowel disease, Crohn’s disease, ulcerative colitis, etc. However, treatment can be made effective if the drugs can be targeted directly into the colon, thereby reducing the systemic side effects. It also plays vital role in systemic delivery of proteins, therapeutic peptides, anti-asthmatic drugs, antihypertensive drugs and anti-diabetic agents. This review article discusses introduction of colon, need and Primary approaches for CDDS (Colon Specific Drug Delivery), which includes prodrugs, pH and time dependent systems and microbially triggered drug delivery system. Newly developed CDDS, which includes pressure controlled colonic delivery capsules (PCDCS), CODE and osmotic controlled drug delivery and also focuses on evaluations of Colon targeted drug delivery in general.
P. Ghugarkar*, P. Kulat, K. Swain and V. Suggala and D. Shaik
Department of Pharmaceutics, Padmashree Dr. Vithalrao Vikhe Patil Foundation’s College of Pharmacy, Vilad Ghat, Ahmednagar, Maharashtra, India.
05 October 2014
08 February, 2015
28 February, 2015
01 July, 2015