COMPARATIVE ANTIANXIETY ACTIVITY EVALUATION OF ARGYREIA SPECIOSA LINN. (ROOTS), CAESALPINIA DIGYNA ROTTLER (ROOTS) AND SPHAERANTHUS INDICUS LINN. (FLOWERS)Abstract
Aim of the present study was a comparative evaluation of antianxiety activity of three traditionally used medicinal plants — Argyreia speciosa (Roots), Caesalpinia digyna (Roots) and Sphaeranthus indicus (Flowers). The activity of various extracts (petroleum ether, chloroform, ethanol and water) of all the three plants was evaluated using elevated plus-maze model. The studies were conducted on lacca mice, and the test materials were administered per oral route. Results indicate that the ethanol extract of C. digyna roots exhibited maximum and significant dose dependent effect at 200 and 400 mg/kg on elevated plus-maze, the results were comparable to the standard antianxiety drug diazepam (2 mg/kg).
Ashwani Kumar*, Jitender Singh and Anupam Sharma
University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh-160014, India
19 March, 2015
30 April, 2015
23 June, 2015
01 October, 2015