COMPARATIVE ANTIOXIDANT ACTIVITY AND BRINE SHRIMP LETHALITY BIOASSAY OF DIFFERENT PARTS OF THE PLANT- ACACIA AURICULIFORMIS
AbstractThe present study was undertaken to evaluate and compare the antioxidant activity and brine shrimp lethality bioassay of different parts (leaf and bark) of the plant Acacia auriculiformis. DPPH radical scavenging and NO scavenging capacity were measured for the determination of antioxidant activity. Ethyl acetate fraction of bark was found to possess highest DPPH radical scavenging activity with IC50 value of 7.80 µg/ml followed by methanol extract of leaf (IC50 value of 7.95 µg/ml). The IC50 value of standard ascorbic acid was 33.77 µg/ml. Incase of NO scavenging activity, n-hexane fraction of root found to have highest scavenging activity with IC50 value of 1.75 µg/ml followed by ethyl acetate fraction of leaf (IC50 value of 3.35 µg/ml). The IC50 value of standard ascorbic acid was 71.06 µg/ml. When compared with other fractions, the methanol fraction of leaf and bark had highest cytotoxic activity with LC50 value of 0.55 and 0.79 µg/ml respectively. This was followed by ethyl acetate fraction of leaf with LC50 value of 0.95 µg/ml. The standard vincristine sulfate had LC50 value of 0.52 µg/ml. Thus, this study suggests that leaf and bark of A. auriculiformis may be a potential source of antioxidant and cytotoxic agents
Article Information
51
875-880
516KB
1000
English
IJPSR
Kaniz Fatima Urmiz, Syeda Yeasmine Chowdhury , Md. Kamal Hossain , Prabhat Bhusal and Kaiser Hamid*
Lecturer, Department of Pharmacy, East West University, Dhaka, Bangladesh
kaiserpharm_1134@yahoo.com
03 November, 2012
12 January, 2013
29 January, 2013
http://dx.doi.org/10.13040/IJPSR.0975-8232.4(2).875-80
01 February, 2013