COMPARATIVE EVALUATION OF ANXIOLYTIC EFFECTS OF VARIOUS EXTRACTS OF OATS (AVENA SATIVA), RICE BRAN (ORYZA SATIVA) AND SPINACH (SPINACIA OLERACEA) IN EXPERIMENTAL ANIMALSAbstract
Aim of the present study was to compare antianxiety activity of various extracts of Oats (OA), Rice Bran (RB) and Spinach (SP) which are rich in phenolics mainly flavonoids and possesses excellent antioxidant property. Flavonoids are reported to have effect on central nervous system, mainly in anxiety disorders. The activity of various extracts (petroleum ether and hydroalcoholic) of all the three plants was evaluated at different doses (50, 100, 200 mg/kg of body weight) using EPM model of anxiety. The studies were conducted on swiss albino mice, and the test materials were administered per oral route. Results indicated that out of all the prepared extracts of the three selected plants, hydroalcoholic extract of Spinach (Spinacia oleracea) exhibited maximum and significant effect at 200 mg/kg of body weight, the results were comparable to the standard antianxiety drug diazepam (2 mg/kg p.o.).
Divneet Kaur, Anjoo Kamboj and Richa Shri *
Department of Pharmaceutical Sciences and Drug Research, Punjabi University, Patiala, Punjab, India
09 May, 2016
19 June, 2016
15 July, 2016
01 October 2016