COMPARATIVE EVALUATION OF DICLOFENAC AND MELOXICAM AS TABLETS AND AS TRANSMUCOSAL MUCOADHESIVE PATCHES IN DENTAL PAIN REDUCTION
AbstractAims and Objectives: To evaluate and compare diclofenac and meloxicam as tablets and as mucoadhesive patches in the control of odontogenic pain. Materials and Methods: 60 patients of either sex with acute dental pain were included in the study. Informed consent was obtained from each patient and they were randomly divided into 4 groups. Group A1 received meloxicam tablets, A2 meloxicam mucoadhesive patches, B1 diclofenac tablets, and group B2 was allotted diclofenac mucoadhesive patches. A 10 cm Visual Analogue Scale (VAS) was used to record pain scores at baseline, 20 and 30 min post-administration. Patients were also given the allotted tablets and patches to be used for 2 days, along with a pain diary to record their VAS scores at 30 min post-administration. Diary was collected and data analyzed on the 4th day. Results: Statistically significant reduction in pain was seen in all 4 groups from baseline to the end of the study period. Overall pain reduction was greater with the mucoadhesive patches than with tablets. Diclofenac patches showed a greater reduction in pain as compared to meloxicam patches (p> 0.05). Diclofenac tablets also showed a statistically significant reduction as compared to meloxicam (p<0.05). Conclusion: The results of this study indicate that mucoadhesive patches resulted in a greater reduction in pain as compared to the tablets. Hence, they can be considered as feasible alternatives to conventional methods of drug delivery and can be used in daily practice.
Article Information
29
2217-2222
366
918
English
IJPSR
A. Chandrashekar *, R. G. Annigeri and J. Thimmasetty
Department of Oral Medicine and Radiology, College of Dental Sciences, Davangere, Karnataka, India.
aditi212121@gmail.com
19 June 2019
13 November 2019
08 February 2020
10.13040/IJPSR.0975-8232.11(5).2217-22
01 May 2020