COMPARATIVE EVALUATION OF HEPATOPROTECTIVE EFFECTS OF EXOTIC FRUITS AND COMMON VEGETABLES EXTRACTS ON CCL4 INDUCED HEPATOTOXICITY: AN IN VITRO STUDYAbstract
Liver toxicity faces a major challenge in world health issues. Many drugs are being withdrawn from the market by Food and Drug Administration (FDA) for causing drug induced hepatotoxicity. In the present study, ameliorative activity of methanoic extracts of different parts (Peel, Pulp and seed) of exotic fruits and vegetables on carbon tetrachloride (CCl4)-induced hepatotoxicity were studied in in vitro condition. Chicken liver cell suspension treated with CCl4 was used for lipid peroxidation (LPO), free radical scavenging and sodium dismutase (SOD) assay. Extracts from different parts of exotic fruits and common vegetables showed potent antioxidant effect. In the present study even, methanoic extract of some unused parts (peel & seed) of vegetables and fruits showed hepatoprotective action, but among all these bottle gourd pulp (vegetable) and passion fruit pulp (exotic fruit) showed the noteworthy hepatoprotective action. Thus it is concluded that, the methanoic extracts of exotic fruits and vegetables was observed to have notable protective activity on CCl4 induced hepatotoxicity.
Kavitha Raj V., J. R. Kumar *, S. Balasubramanian, S. Najunda Swamy, D. Keerthini, N. Shambhavi, B. M. Kanthesh and K. O. Avinash
Division of Biochemistry, Faculty of Life Science, JSS University, Mysuru, Karnataka India
04 April, 2016
02 July, 2016
08 July, 2016
01 August 2016