COMPARATIVE EVALUATION OF PIOGLITAZONE HCL AND GLICLAZIDE -LOADED HPMC-PVA BLEND PATCHESAbstract
Transdermal drug delivery system (TDDS) involving HPMC-PVA patches were prepared as matrix-dispersion system with Pioglitazone HCl (PH) or Gliclazide (GZ) and drug release pattern from these patches were evaluated in-vitro as well as in-vivo. It has been found that 82.41% of Pioglitazone HCl and 70.12% of Gliclazide were released in-vitro in the period of 12 hours and the release patterns was zero-order. In-vivo skin permeation studies in alloxan-induced diabetic rats showed significant improvement on day-to-day diabetic control. Treatment with the patches induced hypoglycemia in normal rats whereas in diabetic rats blood glucose level returned to normal level within 16 hours. These findings suggest that delivery of these drugs through TDDS may overcome the first-pass effect when administered orally and thus gives better glycemic control in diabetic patients.
Md. Kamrul Hasan, Md. Ajijur Rahman, Sharif Mohammad Shahin and Md. Anwar Ul Islam
Professor, Department of Pharmacy, University of Rajshahi, Rajshahi-6205, Bangladesh
06 December, 2015
24 January, 2016
07 February, 2016
01 May, 2016