COMPARATIVE IN VITRO EVALUATION OF COMMERCIAL NIMESULIDE TABLETSAbstract
Five Indian Brands (coded as A,B,C,D,E) of 100 mg Nimesulide tablets were evaluated for various In vitro parameters, i.e. size and shape, uniformity of weight, hardness, friability, content, disintegration time and dissolution profile. All the products met the requirements of British Pharmacopoeia for tablet formulation. The hardness of all the brands was found to be in the range of 4.2-4.4 kg, while friability was less than 1 %. The disintegration time of all brands was found to be in the range of 2min 22 sec to 5min 29 sec. All brands comply the B.P weight variation test while brands A, B, C and D comply the B.P dissolution test except brand E. Formulation additives in the tablet, physical form of the drug used in the tablet and manufacturing process vary from manufacturer to manufacturer which is responsible for the variation in the observed dissolution profiles.
N. B. Mahale*, P. J.Badhan, K. R. Nikam, S. R. Chaudhari
Amrutvahini College of Pharmacy, Sangamner-422 608, Ahmednagar, Maharashtra, India
31 May, 2011
15 July, 2011
17 September, 2011
01 October, 2011