COMPARATIVE IN-VITRO EVALUATION OF VITEX LEUCOXYLON LINN. BARK FOR ANTIOXIDANT ACTIVITYAbstract
Cellular damage arising from free radical is one of the fundamental mechanism underlying a number of human neurodegenerative disorder like diabetes, inflammation, Alzheimer’s disease, autoimmune pathologic and digestive system disorder. Thus antioxidant plays an important role in the treatment of such disease. The present study aims at a comparative evaluation of ethyl acetate, hexane and methanol extract of Vitex leucoxylon Linn. bark for antioxidant activity. Vitex leucoxylon Linn. a medicinal plant of the verbenaceae family, used in traditional medicine for relieving headache and catarrh. HIME was 1.8964 μg/ml after 48 h of incubation. In this study, it was observed that HIME induces a concentration dependent inhibition of HT29 cells, with an IC50 value of 1.8964 μg/ml after 48 h of incubation.
AKHTAR MD S., SHUKLA PADMINI*, SHUKLA PRABODH, SHASHI ALOK, MAHOR ALOK
Department of Pharmacy,Pranveer Singh Institutes of Technology,Bhaunti, Kanpur (U. P.), India
4 December, 2009
20 December, 2009
28 December, 2009
01 January, 2010