COMPARATIVE INVESTIGATION OF TOXICOLOGICAL CHARACTERISTIC AND SPECIFIC BIOLOGICAL ACTIVITY OF THE MEDIUM-CHAIN ALIPHATIC MONO- AND DIPEROXYCARBOXYLIC ACIDSAbstract
The comparative toxicological characteristic in-vitro and antimicrobial activity to perform stability tests of several linear medium-chain aliphatic monoperoxyacids (perC8–C12) and aliphatic diperoxyacid (diperC9) were studied. Substances of peroxide acids: perС8, perС10, perС12, diperoxyazelaic acid (diperC9) are in 5.6; 22.8; 64 and 1.6 times less toxic than reference substance – peracetic acid (perC2). New knowledge concerning а comparative antimicrobial activity of studied medium-chain aliphatic peracids and their thermal sensitivity was obtained. These fundamental stability studies resulted in the emergence of safe antimicrobic agents. Nonanebis(peroxoic acid) and Peroxyoctanoic acid were proposed as an agent in the chemical disinfection prosses for the first time. Medium-chain aliphatic peracids were demonstrated to be very robust. Sufficiently high bactericidal activity was achieved after relatively short exposition times (from 10 min to 2 h for spores of B. anthracoid), at near-ambient temperature (20 °C). In this work, it has been demonstrated how stability studies can underpin rational design of antimicrobic agents that in turn lead to a both safer and economically viable chemical disinfection and sterilization process.
M. Y. Blazheyevskiy, O. V. Prysiazhniuk and O. O. Mozgova *
Department of Physical and Colloid Chemistry, National University of Pharmacy, Kharkiv, Ukraine.
30 December 2019
07 April 2020
11 May 2020
01 January 2021