COMPARATIVE SAFETY AND COST EFFECTIVE ANALYSIS BETWEEN ACECLOFENAC, LORNOXICAM AND DICLOFENAC IN PATIENTS OF MUSCULO SKELETAL DISORDERAbstract
Newer NSAIDs like Aceclofenac and Lornoxicam are being marketed by pharmaceutical industries with claims of better efficacy and safety than conventional NSAIDs like Diclofenac. So this study aims to comparatively assess the safety, efficacy and cost of Aceclofenac, Lornoxicam and Diclofenac in patients of musculoskeletal disorders. Patients presenting with musculoskeletal disorders were randomized into three treatment groups (50 in each). Comparative analgesic efficacy assessment between the three drugs were done by using visual analog scale (VAS) reading on Day-0 and then weekly till 3 weeks; adverse drug reaction (ADR) information were collected by spontaneous reporting from patients and by active surveillance and were recorded in a predesigned proforma. Relative cost was assessed by comparative unit cost price of individual drugs (of different pharmaceutical companies). It was observed that Lornoxicam, Aceclofenac and Diclofenac are equally effective as analgesic. Both Aceclofenac and Lornoxicam have similar ADR profile which is significantly less than that of Diclofenac. Though analgesic activity and safety profile of Aceclofenac is comparable to Lornoxicam, but Aceclofenac is cheaper than Lornoxicam , hence comparatively cost effective.
K.P. Patnaik*, P. Das, S. Hota , B. N. Mohapatra , S. Mohapatra , S. Nayak , S. Panigrahi
Department of Pharmacology, S.C.B. Medical College, Cuttack-753007, Odisha, India
24 May, 2012;
04 July, 2012
21 August, 2012
01 September, 2012