COMPARATIVE STUDY OF ANTIULCER ACTIVITY OF METHANOLIC EXTRACTS OF WATTAKAKA VOLUBILIS (LINN.F.) STAF AND TABEBUIA ROSEA (BERTOL.) DC IN RATSAbstract
The aim of this study was to compare the antiulcer activity of methanolic extracts of Wattakaka volubilis (Linn.f.) Staf and Tabebuia rosea (Bertol.) DC in rats. The anti-ulcer effect was evaluated using Anti secretary model (chemical induced pylorus ligation). Ranitidine were used as standard drugs for ulcer studies. The extracts were administered orally at 500 mg/kg. The result of the present study indicates oral administration of Wattakaka volubilis and Tabebuia rosea produced significant inhibition of the gastric lesions induced by Anti secretary model (Chemical induced pylorus ligation. Comparison was made between two plant extracts and methanolic extract of Wattakaka volubilis than Methanolic extract of Tabebuia rosea. Preliminary phytochemical screenings indicated the presence of alkaloids, flavonoids, tannins, saponins, phenols, terpenoids, glycosides and sugars in both the extracts. This study confirmed the antiulcer properties of this plant as it is used in traditional medicine.
A. Suvarchala Kiranmai*, K. Hemamalini and Uma Vasireddy
TRR College of Pharmacy, Meerpet, Hyderabad, Andhra Pradesh, India
22 July, 2013
05 November, 2013
19 November, 2013
01 December 2013