COMPARATIVE STUDY OF BRAND AND GENERICS OF OMEPRAZOLE CAPSULES AVAILABLE IN THE SAUDI MARKET
AbstractProton Pump Inhibitors (PPIs) are widely used acid suppression medications for many conditions. PPIs class includes many drugs, such as omeprazole, lansoprazole, pantoprazole and esomeprazole, available orally in a tablet/capsule form. PPI’s products have reasonably high prices with quality differences that most healthcare providers must know. Therefore, this study aimed to compare the quality of PPIs for brand and generics in the Saudi market. Gastric ulcers result from an imbalance involving gastric protection and aggressive factors. Gastric protection depends on several factors, such as the release of prostaglandin E2 (PGE2), bicarbonate secretion, gastric mucus production, and gastric mucosal blood flow regulation. Factors leading to gastric offensives are the hypersecretion of H.C.L. or pepsin. Ethanol is well known to induce gastric ulcers via multi-factorial mechanisms such as the impairment of gastric defensive factors like mucus dissolution or by increasing offensive factors such as acid secretion or gastrin release. Our study reveals that the gastroprotective effect of PPIs marketed in Saudi Arabia has significantly protected the gastric mucosa against ethanol challenge.
Article Information
20
3834-3841
1422 KB
620
English
IJPSR
Saira Zahoor, Hajer Alghamdi, Mohammed S. Khalid, Hawra Al-Mubarak and Hassan M. Ghonaim *
Department of Pharmaceutics, College of Clinical Pharmacy, Imam Abdulrahman Bin Faisal University, P.O. Box 1982, Dammam, Kingdom of Saudi Arabia.
hmghonaim@iau.edu.sa
05 December 2022
05 April 2023
28 May 2023
10.13040/IJPSR.0975-8232.14(8).3834-41
01 August 2023
Download