COMPARATIVE STUDY OF HEPATOPROTECTIVE EFFECT PRODUCED BY CUMINUM CYMINUM AND NIGELLA SATIVA AGAINST CISPLATIN-INDUCED HEPATOTOXICITY; WITH HISTOPATHOLOGICAL STUDIESAbstract
Cisplatin is a cytotoxic drug which induced the hepatotoxicity in the albino mice when intra-peritoneally administered at the dose of 10 mg/kg. Administration of cisplatin raised the level of LFT’s enzymes and also reduced the level of antioxidant enzymes in the liver of the mice. Administration of Cuminum cyminum and Nigella sativa extract and silymarin remarkably showed the hepatoprotective effect in the albino mice. Administration of C. cyminum, N. sativa and silymarin decreased the level of ALT, AST, and ALP along with increasing the level of total protein content. It also increased the level of antioxidant enzymes in the liver of albino mice showing its hepatoprotective activity. We found N. sativa has a better hepatoprotective and antioxidant effect than C. cyminum.
N. Abbas*, L. Alyousef, E. M. E. Agabien, E. S. Ahmed, A. S. Ahmed and A. Begum
Department of Medicinal Chemistry, Qassim University, Qassim, KSA.
23 April, 2017
30 October, 2017
24 December, 2017
01 January, 2018