COMPARATIVE STUDY OF HEPATOPROTECTIVE EFFECT PRODUCED BY CUMINUM CYMINUM, FRUITS OF PHYLLANTHUS EMBLICUS AND SILYMARIN AGAINST CISPLATIN-INDUCED HEPATOTOXICITYAbstract
Cisplatin is a cytotoxic drug which induced the hepatotoxicity in the albino mice when intra-peritoneally administered at the dose of 10mg/kg. Administration of cisplatin raised the level of LFT’s enzymes and also reduced the level of antioxidant enzymes in the liver of the mice. Administration of Cuminum cyminum, Phyllanthus emblicus extract and silymarin remarkably showed the hepatoprotective effect in the albino mice. Administration of C. cyminum, P. emblica and silymarin decreased the level of ALT, AST, and ALP along with increasing the level of Total protein content. It also increased the level of antioxidant enzymes in the liver of mice showing its hepatoprotective activity. We found C. cyminum has a better hepatoprotective effect than P. emblica.
Nahid Abbas *, Mamuna Naz, Lamia Alyousef, Eiman Sayed Ahmed and Azra Begum
Department of Medicinal Chemistry *, Department of Pharmacology, Qassim University, College of Pharmacy, Qassim, KSA.
12 October, 2016
30 December, 2016
31 December, 2016
01 May, 2017