COMPARATIVE STUDY OF THREE DIFFERENT APPROACHES USED FOR MANUFACTURING OF ANTIDIABETIC ORODISPERSIBLE TABLETSAbstract
Diabetes mellitus basically a chronic metabolic disorder that results in boosting up blood glucose level to higher concentrations. It is associated with bunch of diseases. To overcome patient’s common problems i.e. throat pain, vomiting, non-compliance, inconvenience and ineffective therapy plan or to enhance patient compliance and effectiveness of therapy scientists have launched orodispersible tablets to attract patients for improving their quality of life. Methods of preparation along with superdisintegrants are the major players in the success of this dosage form. In the present work, antidiabetic orodispersible tablets (ODT’s) containing drugs (Metformin HCl and Glibenclamide) and superdisintegrants (pregelatinize starch and sodium starch glyconate) were prepared by three different techniques i.e. direct compression, effervescent method and sublimation technology. Fifteen formulations (F1-F15) were prepared by using these techniques. Pre-compression studies including rheological analysis (Bulk density, Tapped density, Angle of repose, Carr’s compressibility index, Hausner’s ratio) and compatibility studies such as Differential Scanning Calorimetry (DSC) and Fourier Transform Infrared spectroscopy (FTIR) were performed. Post compression studies on various parameters i.e. tablet hardness, weight variation, friability, disintegration time, dissolution studies wetting time, wetting volume, water absorption ratio, modified disintegration, uniformity of contents and stability studies were conducted according to ICH (International conference on harmonization) guidelines. Finally, results were statistically evaluated by using one way ANOVA test and mean. Formulation F8 prepared by sublimation method was found good relative to disintegration time, wetting volume, wetting time, release studies etc. having short disintegration time and rapid release of drugs.
Asif Mahmood*, Rai Muhammad Sarfraz , Muhammad Zaman , Haseeb Ahsan, Muhammad Ahsan Hafiz and Muhammad Abdullah Akram
Faculty of Pharmacy, University of Sargodha, Sargodha, 40100, Punjab, Pakistan
30 October, 2013
08 February, 2014
24 March, 2014
01 April, 2014