COMPARATIVE SYNTHESIS AND PHYSICOCHEMICAL CHARACTERIZATION OF SUBSTITUTED 2-METHYLQUINOLIN- 4(1H)-ONE BY VARIOUS CONVENTIONAL AND MICROWAVE METHODS
AbstractIn the present work various conventional methods and microwave method for synthesis of substituted quinolone reported. Substituted anilines were taken as a starting material and reacted with ethyl acetoacetate in presence of catalytic amount of acid and cyclized by various cyclisation agents that give the title compounds which differ in its color intensity, reaction time as well in %yield. Based on results we obtain, it has been concluded that microwave method for synthesis of substituted quinolone is more convenient in terms of reaction time and use of solvent.
Article Information
18
5224-5229
591KB
2295
English
IJPSR
Harsha U. Patel and Piyush A. Gediya*
Department of Pharmaceutical Chemistry, Shri Sarvajanik Pharmacy College, Arvind Baug, Mehsana-384001, Gujarat, India.
piyushgediya21@gmail.com
29 April, 2014
17 June, 2014
08 August, 2014
http://dx.doi.org/10.13040/IJPSR.0975-8232.5(12).5224-29
01 December 2014
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