COMPARISON OF ANALGESIC EFFECTS OF 2-BENZOXAZOLINONE AND STANDARDIZED SUPERCRITICAL FLUID EXTRACT OF ACANTHUS ILICIFOLIUS ON ANIMAL MODELS OF PAIN AND MUSCULAR HYPERALGESIA
AbstractThe objective of this study was to evaluate the analgesic properties of supercritical fluid extracts of Acanthus ilicifolius leaves (SCFE-AI) and Benzoxazolinone (BOA) using the acetic acid-induced writhing method, formalin-induced paw lick assay, and carrageenan-induced muscle hyperalgesia. Results demonstrated that SCFE-AI and BOA exhibited potent dose-dependent analgesic activity in all tested models of analgesia. Administration of BOA (30 mg/kg) and SCFE-AI (200 mg/kg) at their maximum dose showed significant peripheral analgesic activity (p<0.05). Oral administration of BOA or SCFE-AI dose-dependently decreased the number of formalin-induced first-phase and second-phase paw licking times in mice. BOA inhibited cold allodynia and mechanical hyperalgesia in a dose-dependent manner, and it was even better than the standard drug. Our results justify the traditional use of A. ilicifolius in the treatment of various diseases associated with pain, such as fibromyalgia.
Article Information
45
5062-5069
647 KB
294
English
IJPSR
AR. Saranya *, T. Ramanathan, KS. Kesavanarayanan and D. Deepika
Department of Biomedical Sciences, Alagappa University, Karaikudi, Tamil Nadu, India.
drarsaranya@gmail.com
18 July 2022
21 September 2023
28 September 2023
10.13040/IJPSR.0975-8232.14(10).5062-69
01 October 2023
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