COMPARISON OF DIFFERENT SUPERDISINTEGRANTS IN DESIGNING OF FAST DISSOLVING TABLETS OF METOPROLOL TARTRATEAbstract
Metoprolol tartrate which is used in the present study is widely used as antianginal properties. Oral bioavailability of metoprolol tartrate is around 40%. In the present work fast dissolving tablets of metoprolol tartrate have been prepared by direct compression method. Formulations were evaluated for precompressional parameters such as angle of repose, % compressibility and Hausner’s ratio. The prepared tablets were evaluated for post compressional parameters such as hardness, friability, thickness, in-vitro dispersion time, wetting time, and water absorption ratio. The prepared tablets were characterized by DSC and FTIR studies. Stability studies were carried out as per ICH guidelines for three months. Effect of superdisintegrants [such as croscarmellose sodium, sodium starch glycolate, crospovidone, and Indion 414] on wetting time, in-vitro dispersion time and stability parameter has been studied. In-vitro dispersion time decreases with increase in concentration of indion 414 upto 9% then increases. Where as in-vitro dispersion time decreases with increase in the concentration of croscarmellose sodium and in-vitro dispersion time increases with increase in concentration of sodium starch glycolate. However in-vitro dispersion time value did not reflect major change with increase in the concentration of crospovidone. Short term stability studies on the formulations indicated that there are no significant change in the in-vitro dispersion time (p<0.05). No chemical interaction between drug and excipients was confirmed by DSC and FTIR studies. From this study it is concluded that fast dissolving tablets could be prepared by direct compression method using different superdisintegrants enhanced dissolution will lead to improved bioavailability, improved effectiveness of metoprolol tartrate.
N. G. Raghavendra Rao *, Ketan Thube, Ram Pentewar and V.B Suryakar
Department of Pharmaceutics, Luqman College of Pharmacy, Old Jewargi road, Gulbaraga, Karnataka, India
31 January, 2010
10 March, 2010
20 March, 2010
01 April, 2010