COMPARISON OF RETABOLIL, 4-THIAZOLIDINONE DERIVATIVE (LES-2222) AND TESTOSTERONE ACTION ON THE ACTIVITY OF THE ANTIOXIDANT DEFENCE ENZYMES IN RATS UNDER FOOD DERIVATION

The manuscript devoted to investigation of some patterns of the mode of action of retabolil, compound LES-2222 (new thiopyrano[2,3-d]thiazole derivative (2-(2-Oxo-5a,11b-dihydro-5H,6H-7-oxa-1,4-dithia-3-aza-cyclopenta[c] phenanthren-3-yl)-N-(3-trifluoromethyl-phenyl)-acetamide) – synthesized at the Department of Pharmaceutical, Organic and Bioorganic Chemistry) and testosterone in rats under food deprivation. The changes of the activity of antioxidant enzymes – glutathione peroxidase (GPO) and catalase (CAT) were investigated in the different tissues under food deprivation and compounds treatment. The effects of all tested compounds were similar. The GPO activity decreased under the LES-2222 application in the liver and kidney and was increased in spleen and testes, but in the myocardium and skeletal muscle its level was normalized. Testosterone and retabolil treatment did not change the GPO activity in the liver and spleen. While, the decrease of activity level in kidney and skeletal muscle and normalisation in the myocardium and testes were detected. The changes of CAT activity under the tested compounds action were noticeable, but not statistically significant in the liver and testes. Significantly increased level of CAT activity in the spleen was detected. In the skeletal muscle and myocardium and kidney tissues the enzyme levels were unchanged.