COMPARISON OF VARIOUS NATURAL SUPERDISINTEGRANTS IN THE FORMULATION OF FAST DISSOLVING CARVEDILOL TABLETAbstract
In the present investigation, fast dissolving tablets of Carvedilol were formulated by using various natural superdisintegrant like Plantago ovata, Lepidium sativum, Fenugreek and Guar gum. A Direct compression method was used to prepare fast dissolving tablets containing Carvedilol as a model drug using natural superdisintegrants. Prepared formulations were evaluated for Precompression parameters such as micromeritic properties like angle of repose, %compressibility and Hausner’s ratio. Tablets were also subjected to Postcompression analysis for the parameters such as weight variation, hardness, and friability, in vitro disintegration time, wetting time, drug content and in vitro dissolution study. The results concluded that amongst all formulations, the formulation prepared with mucilage of Plantago ovata showed better disintegrating property as well as the release profile than the other used natural superdisintegrant.
Vikas Sharma* and Vandana Arora
Lloyd Institute of Management & Technology, Mahamaya Technical University, Greater Noida, Uttar Pradesh, India
26 June, 2012
22 September, 2012
28 September, 2012
01 October, 2012