COMPARITIVE REVIEW ON ANTI-ULCER ACTIVITY OF SOME MEDICINAL PLANT EXTRACTSAbstract
Peptic ulcer is an excavation of mucosa and may extend to the submucosal layer. The bacterium Helicobacter pylori is regarded as the most common cause of infection. Long-term use of NSAIDs (non-steroidal anti-inflammatory disease drugs) like Aspirin, Diclofenac, and Naproxen and stress were also regarded as causes of ulceration. Ancient technology of synthesizing and utilizing plant-based medicine is known from time immemorial. Chronic and complicated diseases have been cured with plant-based products. Considering their importance in manufacturing new medicines, their efficacy and safety have become a major concern. This literature review reviews some investigated plants that have shown promising results in mitigating peptic ulcers at different doses. Preliminary phytochemical screening of these herbs has shown the presence of important secondary metabolites like flavonoids, alkaloids, terpenoids, tannins which are responsible for the anti-ulcer activity. Acute toxicity studies have proved the safety of the selected plant extracts. This article reviews the overall active constituents, anti-ulcer, gastro protective activity of some medicinal plants investigated between 2015-2022.
Leela Kalyani Martha, Ekshita Sai Thummuru, Vinitha Vemishetty, Sai Sruthi Perabattula and Anil Kumar Sagi *
Department of Pharmacology, Shri Vishnu College of Pharmacy, Bhimavaram, Andhra Pradesh, India.
20 April 2022
16 June 2022
30 June 2022
01 January 2023