COMPERATIVE EFFICACY OF THREE INDIGENOUS MEDICINAL PLANTS (TURMERIC, GARLIC, AND ALOE) WITH LOCALLY AVAILABLE PATENT DRUG NEBANOL® AGAINST ARTIFICIALLY INDUCED WOUND IN GUINEA PIGS

The experiment was performed at the Department of Pharmacology in collaboration with the animal house Microbiology Department, Bangladesh Agricultural University, Mymensingh during the period from Jan 2005 to May 2005. To complete the research work following steps were followed.The aim of this study was to assess the possible comparative efficacy of Turmeric (Halud), Garlic (Rashun) and Aloe (Ghrita kumari) with Antibiotic Nebanol (Neomycin Sulphate and Bacitracin Zinc) on artificially induced wound in 2.5 cm length and 0.5 cm depth were made on the two thigh muscles an experimental model. Twenty five guinea pigs of both sexes age ranged between 6 to 8 months were divided into five groups (each group containing five animals). The first, second and third groups received herbal medicine e.g.; Turmeric paste, Garlic paste, Aloe gel and fourth group received Antibiotic Nebanol powder (Neomycin Sulphate and Bacitracin Zinc) respectively. The fifth/control groups were observed without medicine. Turmeric, Garlic, Aloe & Nebanol treatment reduced the wound within 12, 15, 17 & 14 days respectively. On the other hand, wound in control group was automatically reduced within 21 days. The present study showed that Turmeric was best effective among all & was found better than antibiotic Nebanol (Neomycin Sulphate and Bacitracin Zinc). It is concluded that among 3 indigenous preparations Turmeric may be used against skin wound because it is less expensive, easily available, having less side effect.