COMPLEXES OF COBALT(II), NICKEL(II) AND ZINC(II) WITH SCHIFF BASES DERIVED FROM 4-ANISALDEHYDEAbstract
Co(II), Ni(II) and Zn(II) complexes of Schiff bases derived from condensation of 4-anisaldehyde with anisidine, (AAN) or 2,4 dinitrophenylhydrazine ,(ADN) have been prepared in 1:2 molar ratio (metal:ligand). The compounds have been characterized using elemental analysis, electronic spectra, infrared and molar conductance measurements. The infrared data revealed that the ligand, AAN behaved as a tridentate ligand. It coordinated to the metal ions via the N and two O atoms of the ligand. ADN behaved as a bidentate ligand coordinating through the O and N atoms of the ligand. The electronic spectral data indicates that the compounds are six coordinate. The molar conductance values showed that the complexes are non-electrolytes. The compounds were screened in vitro for antibacterial activity against some pathogenic bacteria: Escherichia coli, Pseudomonas aeruginosa, Salmonella typhi, Bacillus subtilis and Staphylococcus aureus using the agar-well diffusion method. The synthesized Schiff base complexes exhibit higher antibacterial activity against the tested pathogens compared to the free Schiff base because of chelation.
N.P. Ndahi*and Y.P. Nasiru
Department of Chemistry, Faculty of Science, University of Maiduguri, Maiduguri, Borno State, Nigeria
25 May, 2012
21 July, 2012
19 September, 2012
01 December, 2012