COMPUTATIONAL DESIGN, SYNTHESIS AND IN-VITRO EVALUATION OF NOVEL ARYL FLUORO HYDRAZIDE DERIVATIVES
AbstractInfectious diseases continue to be a major cause of morbidity and mortality, and the current antimicrobial resistance crisis has the potential to worsen this problem. To address this issue, new antimicrobials and strategies for fighting antimicrobial resistance are needed. In this study, we synthesized two arylflouro hydrazide derivatives by reacting various selected hydrazides (4-Fluorobenz-hydrazide) and different substituted aromatic aldehydes (3-Bromo-2-fluoro benzaldehyde and 5-Bromothiophene-2-carboxaldehyde). The compounds were characterized using IR, 1H NMR, and 13C NMR. The synthesized derivatives were also pharmacologically evaluated using molecular modeling. The biological activity was assessed using an antimicrobial assay, which showed significant activity compared to the standard Ampicillin. Among the synthesized compounds, PD2B exhibited a higher zone of inhibition with 10 mm in E. coli and 12 mm in B. subtilis, whereas PD2F showed a zone of inhibition with 3 mm in E. coli and 8 mm in B. subtilis.
Article Information
34
2939-2947
1553 KB
268
English
IJPSR
K. Sreena *, P. Ashique, T. R. Pavithra and Pooja Lakshmi
Department of Pharmaceutical Chemistry, Crescent College of Pharmaceutical Sciences, Payangadi, Kannur, Kerala, India.
sreenasujith@gmail.com
30 September 2022
26 December 2022
17 April 2023
10.13040/IJPSR.0975-8232.14(6).2939-47
01 June 2023
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