CONFORMATIONAL ANALYSIS: A REVIEW
AbstractConformational analysis is an important step in molecular modeling as it is necessary to reduce time spent in screening of compounds for activity. Most drugs are flexible molecules with the ability to adopt different conformations by means of rotation about single bonds. Conformations play an important role in prediction of not just physico-chemical properties but also the biological activity of the drug. This review details the various methods involved in conformational analysis. The major objective of conformational analysis is to gain insight on conformational characteristic of drugs and also to identify the relation between the role of conformational flexibility and their activity.
Article Information
4
34-41
593KB
4079
English
IJPSR
Jasmine Uthuppan* and Kriti Soni
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Jamia Hamdard, Hamdard Nagar, New Delhi-110062, India
jasmine239d@yahoo.com
22 September, 2012
17 October, 2012
17 December, 2012
http://dx.doi.org/10.13040/IJPSR.0975-8232.4(1).34-41
01 January, 2013
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