CONTEMPORARY APPROACHES FOR BI-LAYER TECHNOLOGY OF DRUGS THROUGH ORAL ROUTE: AN OVERVIEWAbstract
Bi-layer tablet technology for bimodal release of drug and co-administration of drugs via oral route has been engaged a significant place in the field of drug delivery technology. At present, several pharmaceutical companies are developing bilayer tablet for co-administration of drugs to improve the therapeutic efficacy as well as to reduce the chances of drug-drug interaction. This review indicates the different aspects of drug release mechanism, different strategies of drug release, various techniques for bilayer tablet, and the influence of different process and formulation parameters must be considered during the development of bilayer tablet. Bi-layer tablet is suitable for sequential release of two drugs in combination, separate two incompatible substances, and also for sustained release tablet in which one layer is immediate release as initial dose and second layer is maintenance dose.
Rishikesh*, Mohiuddin Ahmed Bhuiyan, S. M. Ashraful Islam, Irin Dewan, Md. Asraful Islam and Md. Sium Ul Hossain Miah
Department of Pharmacy, University of Asia Pacific, Dhanmondi, Dhaka-1209, Bangladesh
15 December, 2012
21 March, 2013
29 March, 2013
01 April, 2013