CORRELATION BETWEEN URINARY MICROALBUMIN, GLYCOSYLATED HAEMOGLOBIN AND SERUM MAGNESIUM IN TYPE 2 DIABETIC PATIENTSAbstract
Background and Objectives: Diabetes mellitus comprises a group of common metabolic disorders that share the phenotype of hyperglycemia. One of the leading causes of diabetes mellitus related morbidity and mortality is diabetic nephropathy. The earliest stage of diabetic nephropathy is Microalbuminuria, which is the excretion of extremely small quantities of albumin in the range of 30 – 300 mg/day. Hypomagnesaemia may be a risk factor for the progression of complications in type 2 diabetes mellitus. Material and Methods: The material for the present study comprised of 60 patients of type2 diabetes mellitus. Glycosylated hemoglobin, serum magnesium, and urinary microalbumin were measured. Results: It was found that the glycemic control, as indicated by glycosylated hemoglobin, is related significantly to microalbuminuria. Poor glycemic control leading to renal damage causes microalbuminuria. A significant inverse correlation between serum magnesium and urinary microalbumin levels was also observed. Conclusion: Estimation of urinary microalbumin, glycosylated hemoglobin and serum magnesium should be routinely done in confirmed cases of type 2 diabetes mellitus.
A. Mishra *, D. Tiwari, N. Sharma and P. Thapa
Department of Biochemistry, SRMS IMS, Bhojipura Bareilly, Uttar Pradesh, India.
13 March 2014
09 August 2014
23 August 2014
01 October 2014