CRUDE ROOT EXTRACT OF ASPARAGUS RACEMOSUS AMELIORATES ACETAMINOPHEN INDUCED UREMIC RATS.Abstract
Now days, herbal medicines are widely used to treat, manage and cure the kidney diseases as well as reduce uremia, acute nephritis & nephritic syndrome. The present study was to evaluate the antiuremic and antioxidative effect of Asparagus racemosus (AR) on acetaminophen induced uremic male rats. The study was designed with 36 male albino rats which were randomly divided into 6 groups. Group I animals were provided normal food and water ad libitum, Group II, III, IV, V and VI received acetaminophen intraperitoneally at the dose of 500 mg/kg body weight/day for 10 days. Methanol, aqueous, hydromethanol, and hexane extract of AR at the dose of 500mg/kg body weight/day were fed orally on the 11th day and continue for next 15 days to group III, IV, V and VI respectively. After 25 days, group-II animals showed significantly increased (p<0.05) plasma urea, creatinine, sodium. Elevation of lipid peroxidation was noted by measuring Malondialdehyde level in both plasma and kidney tissues than Group I, III, and V. Plasma Potassium, plasma and tissue superoxide dismutase and catalase levels were significantly decreased (p<0.05) in animals of Group III and V as Group I. So it was concluded that the methanol and hydromethanol extract of AR conferred nephroprotective and antioxidative properties against acetaminophen induced uremia.
Suchismita Roy, Koushik Das, Shreya Mandal, Shrabani Pradhan, Arpita Patra and Dilip Kumar Nandi*
Research Unit, Developed by Department of Nutrition, Physiology & Microbiology, Raja N. L. Khan Women’s College, Midnapore-721102, Dist- Paschim Medinipur, West Bengal, India
26 March, 2013
22 May, 2013
21 July, 2013
01 August, 2013