CUBOSOME: A NOVEL VESICULAR DRUG DELIVERY SYSTEMAbstract
Cubosomes are square and rounded particles with internal cubic lattice. Cubosomes are thermodynamically stable and consist of honeycombed (cavernous) structures separating two internal aqueous channels and a large interfacial area. Cubosomeisa novel biocompatible drug delivery system whose diameter size range from 10–500 nm. Cubosomes possessa great significance in the field of cosmeceuticals and Pharmaceuticals due to their unique features and become an attractive choice of vehicle for in-vivo drug delivery due to their low cost, safety, efficacy, and versatility for controlled release application and functionalization. Cubosomes have a very simple method of preparation. Cubosomes are nanoparticles that are self-assembled liquid crystalline particles of certain surfactants with a proper ratio of water with a microstructure that provides unique properties of practical interest. The word bicontinuous refers to the division of the two continuous but non-intersecting aqueous regions by a lipid bilayer that is twisted into a space-filling structure. The controlled release application of these nanoparticles is of great significance in cosmeceutical and pharmaceutical fields, and they can be characterized by various evaluation parameters. The low cost of the raw materials, versatility, and the potential for controlled release through functionalization make them an attractive vehicle for several in-vivo drug delivery routes. This review article other than this mainly focuses on the history, structure, types, advantages, disadvantages, and applications of cubosomes.
Ashwini A. Bachhav *, Prashant L. Pingale, Chandrashekhar D. Upasani and Satish A. Ahire
NDMVPS’s College of Pharmacy, Nashik, Maharashtra, India.
11 May 2021
24 December 2023
27 December 2023
01 February 2024