CURRENT ADVANCES IN SUSTAINED-RELEASE INJECTABLE PREPARATIONS
AbstractIn recent years, there has been a great deal of interests in developing sustained-release systems which can prolong the therapeutic effect, decrease adverse side effects, and reduce administration frequency. Nowadays, the oral sustained-release preparations account for a larger market share comparing to other sustained-release forms, mainly because of its noninvasive pain-free administration. However, the hostile environment of gastrointestinal tract and first-pass effect may lead to low bioavailability of some drugs, such as some proteins, peptides, and hormones. In this paper, the latest research progresses of some new-model sustained-release injectable dosage forms were introduced, including microsphere, microcapsule, liposome, polymeric micelle, and in situ forming system.
Article Information
2
2888-2896
642KB
1519
English
IJPSR
Liandong Hu*, Hailei Zhang, and Weihua Song
Key Laboratory of Pharmaceutical Quality Control of Hebei Province & School of Pharmaceutical Sciences, Hebei University, Baoding, 071002, PR China
hbupharm@126.com
27 April, 2012
16 June, 2012
28 August, 2012
http://dx.doi.org/10.13040/IJPSR.0975-8232.3(9).2888-96
01 September, 2012
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