CURRENT STATUS AND FUTURE INNOVATIONS IN TRANSDERMAL DRUG DELIVERYAbstract
Transdermal drug delivery system (TDDS) in comparison to conventional system offers sustained drug release as well as decrease the intensity of action and decrease in the side effects associated with conventional therapy. Presently only about 40 products of more than 20 drug molecules are available in market. The barrier property of the stratum corneum is the main obstructer in the release of drug from the transdermal patch. Various approaches to overcome this barrier function of skin have been broadly studied. Innovations in technologies continue to occur at a positive rate, making the technology a productive and exciting area of innovation, research and product development. In this review, various new development in the field of TDDS are included which are intended to be a need base system. In this review, we have summarized various physical and chemical approaches for transdermal flux enhancement as well as the application of electricity, ultrasound, microneedle and chemical enhancers.
Shalini Chhabaria*, Ankur Namdeo, Rajat Kheri, Gaurav Saraogi and Akhilesh Singhai
Lakshmi Narain College of Pharmacy, Kalchuri Nagar Raisen Road, Bhopal- 462 021, Madhya Pradesh, India
24 April, 2012
14 May, 2012
27 July, 2012
01 August, 2012