CYTOPROTECTIVE EFFECTS OF MORINDA CITRIFOLIA (NONI) ON CULTURED LENS EPITHELIAL CELLSAbstract
Oxidative stress is one of the factor that initiating development of cataract and describes the events leading to lens opacification, generally cataract is a clouding of the lens of the eye that will affect the vision either partially or completely. Proteins that are present in the lens begin to break down and the lens becomes cloudy. This will be avoided by taking external food supplements that are rich in antioxidants. Morinda citrifolia fruit (Noni) juice is rich in antioxidants. This food supplement with lot of nutraceuticals support good health and diminish the effects of aging. To investigate the involvement of Noni in protection against oxidative stress, chick lens epithelial cells were subjected with hydrogen peroxide (100 µM H2O2) over a time course, with and without pre-treatment of Noni fruit extract and commercial Noni. Na+K+ATPase enzyme estimation was performed to determine the role of Noni juice and Noni extract. Our study revealed that Noni juice and extract preserved physiological functions of chick and human lens epithelial cells when subjected to oxidative stress.
S. Konada *, S. Rentala, S. Dhurjeti and U. S. N. Murthy
Department of Biotechnology, Institute of Science, GITAM University, Visakhapatnam, Andhra Pradesh, India.
06 August, 2017
23 October, 2017
21 November, 2017
01 May, 2018