CYTOTOXIC ACTIVITY OF METHANOLIC EXTRACTS OF JUSTICA ADHATODA
AbstractThe aim of the study is to observe the cytotoxic activitiy of methanolic crude extracts of root of Justica adhatoda a plant belonging to the family Acanthaceae. The root of Justica adhatoda was extracted with organic solvent and the extracts were used for the observation of cytotoxic activitiy. Crude extracts (n-hexane, ethyl acetate and chloroform soluble fraction) of Justica adhatoda, were screened for cytotoxic activity using brine shrimp lethality bioassay. A reputed cytotoxic agent vincristine sulphate was used as a positive control. From the results of the brine shrimp lethality bioassay it can be well predicted that n-hexane, ethyl acetate and chloroform soluble fraction of methanolic crude extracts possess cytotoxic principles (with LC50 1.129mg/ml, LC50 1.402 mg/ml and LC50 2.130 mg/ml respectively) comparison with positive control vincristine sulphate (with LC50 0.563 mg/ml).
Article Information
40
2655-2657
514KB
1383
English
IJPSR
Mumita Meskat and Mohammad Musarraf Hussain*
Assistant Professor, Department of Pharmacy Jagannath University, Dhaka-1100, Bangladesh
m.musarraf.hussain@gmail.com
04 April, 2012
28 May, 2012
29 July, 2012
http://dx.doi.org/10.13040/IJPSR.0975-8232.3(8).2655-57
01 August, 2012
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