DEGRADATION STUDY OF LIPOSOME DRUG DELIVERY PREPARED WITH PALM OIL; USING 1H NMRAbstract
This study aims to utilize natural palm oil in the formulation of liposome and evaluate its stability and degradation via the 1H NMR technique. In this study, the conventional method was used to prepare liposome consisting 0, 5, 10, 15, 20 and 25% of palm oil in their structure, and the liposome were characterized in vitro afterwards. The chemical degradation of liposome in the presences of blood component was detected using 1H NMR after incubation period of 2 hours, one day and one week. According to 1H NMR spectrums, samples that lack palm oil or those exceeding 15% palm oil concentration underwent decomposition in the first 2 hours, while samples that were loaded with 5,10 and 15% or palm oil showed no such degradation. However, after being incubated for a day with serum component, the samples loaded with 10 and 15% palm oil remained stable and did not succumb to degradation. It can be surmised that this approach is a viable analytical concept based on the chemical characteristics and the stability of liposomal drug carriers, which complements that of conventional analytical techniques.
B. Sabeti, Md. Ibrahim bin Noordin, S. Mohd , R. Hashim , A. Dahlan and H. Akbari Javar *
Department of Pharmaceutics, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
22 November, 2014
20 January, 2015
27 March, 2015
01 July, 2015