DENDRIMERS: NOVEL DRUG NANOCARRIERSAbstract
Dendrimers are unique class of the polymer which is characterized by its extensively branched 3D structure that provides a high degree of surface functionality and versatility. Many drugs used in various therapies are facing difficulties like toxicity or nonspecific targeting. New delivery technologies could help to overcome this challenge. Nanostructures with uniform and well-defined particle size and shape are of eminent interest in biomedical applications because of their ability to cross cell membranes and to reduce the risk of premature clearance from the body. Hydrophobic drugs can be complex within the hydrophobic dendrimers interior to make them water-soluble or drugs can be covalently coupled onto the surface of the dendrimers. Structural features of this nanomolecule can be effectively modified for drug delivery in the field of pharmaceutical sciences and biotechnology. Present review deals with various applications along with relevant examples of dendrimers in brief.
U. Y. Kandekar*, P. D. Chaudhari , V. S. Tambe , V. S.Vichare and S. N.Dhole
PES’s Modern college of Pharmacy (For Ladies), Borhadewadi, Dehu- Alandi Road, Moshi, Pune, Maharashtra, India
21 January, 2011
26 February, 2011
12 April, 2011
01 May, 2011