DESIGN AND CHARACTERISATION OF AMOXYCILLIN LOADED DENTICAP USING MUCOADHESIVE GUM ISOLATED FROM FRUIT PULP OF ZIZIPHUS MAURITIANA L.
AbstractNovel drug delivery approach by using natural polymers is a newer area of formulation development. The oral drug delivery in the buccal cavity to treat the dental infections has some limitations such as slow onset of actions and is also affected by the first pass metabolism. In order to overcome these challenges plant derived mucoadhesive gum from the fruit pulp of Ziziphus mauritiana L.(ZM) is used in the preparation of Denticap and evaluated in vitro for to analysis its sustained release action. Antibacterial drug Amoxycillin Trihydrate has been taken as the model drug. The denticap was formulated using Carbopol 934P, Z Mgum, Ethyl cellulose and ethanol by solvent evaporation technique. The physicochemical parameters such as swelling index, surface pH, tooth adhesion test etc were carried out. The swelling % ranges from 40-55%. The tooth adhesive strength and pH was 45g and 6.7 respectively. The cumulative drug release from the ZM denticap was found to be 67% at 30 hr. The drug release kinetic study shows that formulation follows diffusion mechanism. The antibacterial study against various oral infection pathogens like Lactobacillus acidophillus, Staphylococcus aureus, Porphyromonas Gingivalis and Streptococcus mutans showed that the ZM gum possess certain antibacterial activity. SEM study shows the surface morphology of the denticap. The stability study following ICH guidelines shows that the formulation is stable. The formulated Denticap using ZM gum is a newer approach for sustained delivery of drug for treatment of dental infections.
Article Information
32
2401-2408
1252 KB
298
English
IJPSR
Priyanka Ray, Sumana Chatterjee * and Prerona Saha
Department of Pharmacy, Guru Nanak Institute of Pharmaceutical Science and Technology, 157/F Nilgunj Road, Sodepur, Kolkata, West Bengal, India.
sumana.chatterjee@gnipst.ac.in
28 August 2022
15 October 2022
17 November 2022
10.13040/IJPSR.0975-8232.14(5).2401-08
01 May 2023