DESIGN AND CHARACTERIZATION OF TASTE MASKED DEXTROMETHORPHAN HBR ORAL DISINTEGRATING TABLET BY USING NATURAL SUPERDISINTEGRANTSAbstract
Objective: Our work was to develop an ordispersible tablet of Dextromethorphan HBr with acceptable palatability to help patients of all age groups. Methods: The bitter taste of the drug was masked by entrapping the drug into Eudragit RL 100. The microspheres were prepared from solvent evaporation method. The effect of particle size, drug entrapment efficiency, % yield and % drug release of the microspheres was studied. Drug loading increased significantly with increasing the drug polymer ratio. Dextromethorphan was than further transformed into orodispersible tablet by using Hibuscus and Fenugreek as a superdisintegrants by using direct compression method. Physiochemical parameters and animal toxicity study of dried mucilage obtained from Hibiscus and Fenugreek were performed. In-vitro disintegration and in-vitro dissolution was carried out to observe the disintegration time and sustain release of drug. Results: In-vivo taste masked study was performed on albino rats. SEM, DSC and FTIR were done for identification, compatibility study and surface morphology. The or dispersible tablet made from sustained release microspheres showed release up to 10 h. Conclusion: All the results of ODTs prepared from natural super disintegrants were compared over synthetic. ODTs of natural superdisintegrants showed good results over the synthetic superdisintegrants.
Shivangi Singh *, Abid Malik and Navneet Verma
Faculty of Pharmacy, IFTM University, Moradabad, Uttar Pradesh, India.
15 January 2021
29 January 2022
22 February 2022
01 March 2022