DESIGN AND DEVELOPMENT OF BENDAMUSTINE LOADED CHITOSAN NANOPARTICLE IN-VITRO CYTOTOXICITYAbstract
Nanoparticles represent one of the alternatives in the treatment of cancer chemotherapy. In the present study, the prime objective was to formulate anti-cancer drug, bendamustine into polymeric chitosan nanocarrier system for its sustained release and passive targeting mechanism. Based on particle size, zeta potential and polydispersity index, F3 was selected as the optimized formulation. The SEM images revealed nanostructure with linear/rod shape enabling better internalization. The X-ray powder diffraction analysis clearly indicates reduction in crystallinity of bendamustine in nanoparticles. The nanoparticle formulation showed good results in terms of assayed drug content and encapsulation efficiency. The in-vitro permeation studies using egg membrane revealed that F3 formulation showed a sustained drug release for 28 h with an initial burst release within 1 h.
C. Sankar *, S. Muthukumar, G. Arulkumaran, S. Shalini, R. Sundaraganapathy and N. Vanitha
Department of Pharmaceutics, KMCH College of Pharmacy, Coimbatore, Tamil Nadu, India.
03 May 2019
16 August 2019
01 September 2019
01 February 2020