DESIGN AND DEVELOPMENT OF ORODISPERSIBLE FILM OF MIDODRINE HYDROCHLORIDE
AbstractThis work aimed to develop and evaluate fast dissolving strip of Midodrine hydrochloride to overcome the conventional dosage form’s limitations and enhance dissolution rate, fast onset of action and improved patient compliance. Various batches of the mouth-dissolving film were prepared by using various grades of hydroxypropyl methylcellulose (HPMC) polymer and plasticizers such as Polyethylene Glycol 200, Polyethylene Glycol 400, Polyethylene Glycol 600 and Glycerin, used for the preparation of film by solvent casting method. The estimation was carried out using phosphate buffer pH 6.8 as a solvent using a double-beam spectrophotometer at 289nm. FTIR and DSC studies showed no interaction between drugs, polymers, or other additives. The prepared film was evaluated for transparency and surface texture, thickness, tensile strength, folding endurance, disintegration time, drug content, uniformity and in-vitro drug release study. Midodrine hydrochloride mouth dissolving film was prepared successfully by solvent casting method and that might be an alternative route of drug delivery system of conventional dosage forms with many advantages.
Article Information
43
4038-4045
2453 KB
411
English
IJPSR
Nirav S. Patel, Hitesh D. Karen * and Mona A. Gupta
Department of Pharmaceutics, Shri Sarvajanik Pharmacy College, Shri Sarvajanik Vidhya Sankul, Near Arvind Baug, Mehsana, Gujarat, India.
hdkaren1107@gmail.com
08 December 2022
25 March 2023
28 May 2023
10.13040/IJPSR.0975-8232.14(8).4038-45
01 August 2023
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